Stroke-IMPaCT

This study will investigate the links between the immune system and cognitive decline after stroke.

Results of this study will be used to inform the development of targeted treatments and improved recovery for people who have a stroke in the future.

The Stroke-Immune Pathways and Cognitive Trajectory (Stroke IMPaCT) study is funded by the Leducq Foundation. It is being carried out by a team of researchers led by Professor Craig Smith at Salford Royal in collaboration with The University of Manchester and Stanford University.

• Aged 45+
• Have at least one of the following- diabetes, high blood pressure, high cholesterol, previous heart attack, vascular disease
• No previous stroke, TIA (transient ischaemic attack), brain haemorrhage, brain injury or dementia
• Not taking immunomodulating or immunosuppressant medicines.

• Salford Royal Hospital (part of the Northern Care Alliance)

Taking part will involve one of the following:

Option one

Attend up to three appointments (approx 30 minutes each) over 18 months.

You will be asked to provide basic medical, health and demographic information and donate a sample of blood at each appointment.

Option two

Attend up to six appointments over two years (total appointment time approx 10 hours)

• On two occasions you will be asked to provide basic medical, health and demographic information and donate a sample of blood (approx. 30 minutes)
• On two occasions you will have an assessment of your cognitive function and mobility (approx 2.5 hours)
• On two occasions you will have a brain scan (approx 1 hour)

All participants will be provided with transport or compensated for travel costs. Those completing option two will receive £30 for each brain scan appointment.

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